For this case, the possible prenatal diagnostic tests that can be done are:
> Amniocentensis: alpha-fetoprotein in amniotic fluid (by 14 weeks' gestation) suggests open neural tube defects.
>Ultrasound: this readily diagnose the condition (as reflected in the case)
> Fetal MRI: Useful when maternal habitus renders ultrasound studies suboptimal.
Identifies associated anomalies, i.e., cerebral migration disorders,
diastematomyelia, callosal anomalies. (van Zalen-Sprock et al., 1995).
Laboratory Tests Prenatal:Prenatal:Maternal serum alpha-fetoprotein levels. Elevated alpha-fetoprotein level at 16–18 weeks suggests fetal open neural tube defects, indicating further prenatal evaluation and genetic counseling.
Reference: van Zalen-Sprock RM, van Vugt JM, van Geijn HP. First and early second
trimester diagnosis of anomalies of the central nervous system.
J Ultrasound Med 1995;14:603–610. Electronic Version available at Medline.