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    D4 Response to Treatment on UTI

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    *alexus
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    D4 Response to Treatment on UTI

    Post  *alexus on Fri 10 Jul 2009, 11:04 pm

    Zano/Balajadia response to Treatment on UTI

    Optimal duration of antibiotic therapy for uncomplicated urinary tract infection in older
    Women: a double-blind randomized controlled trial


    Thomas Vogel, René Verreault, Marie Gourdeau, Michèle Morin, Lise Grenier-Gosselin, Louis Rochette
    FEB. 17, 2004


    The optimal duration of antibiotic therapy in older patients with uncomplicated urinary tract infection(UTI) is still a matter of debate. The aim of this randomized controlled double-blind noninferiority trial was to compare the efficacy and safety of 3-day and 7-day courses of oral ciprofloxacin for uncomplicated symptomatic UTI in older women.


    A total of 183 women at least 65 years of age with acute uncomplicated UTI were recruited from ambulatory clinics and hospital acute care units. Patients with pyelonephritis, contraindications to fluoroquinolones, recent use of antibiotics, urinary tract abnormalities and diabetes mellitus were excluded.
    Women were randomly assigned to receive either ciprofloxacin 250 mg twice daily orally for 3 days followed by placebo for 4 days (the 3-day group, 93 patients) or ciprofloxacin 250 mg twice daily orally for 7 days (the 7-day group, 90 patients). Bacterial eradication, clinical improvement and occurrence of adverse events were determined 2 days after completion of treatment, and occurrence of reinfection or relapse were determined
    6 weeks after completion of treatment. Bacterial eradication and relapse were determined by urine culture. Double-blind procedures were maintained throughout data collection.


    The proportion of patients with bacterial eradication at 2 days after treatment was 98% (91/93) in the 3-day group and 93% (83/89) in the 7-day group (p = 0.16). The frequency of adverse events, including drowsiness, headache, nausea or vomiting, and loss of appetite, was significantly lower in the 3- day group.


    Urinary tract infection has known to be a common and frequently diagnosed infection among older adult, Hence prompt researches such as this type brought a vast significance in treating and taking care of the client with such infection. The result of the study suggest that the shorter course antibiotic therapy for 3 days is not mediocre or inferior to a 7 day treatment of uncomplicated symptomatic UTI in older women, thus low medical treatment cost will be use and a risk for various complications will be minimize.

    Thomas Vogel, René Verreault, et al. Optimal duration of antibiotic therapy for uncomplicated urinary tract infection in older Women: a double-blind randomized controlled trial. Hôpital du St-Sacrement,
    Bureau L2–26, 1050, chemin Sainte-Foy, Québec QC G1S 4L8;

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