meg_crow Wed 12 Aug 2009, 10:48 pm
Fetal Fibronectin (fFN): A Test for Preterm Delivery
The American College of Obstetrics and Gynecology recommends that screening for the presence of fetal fibronectin (fFN) may be useful for some pregnant women with symptoms of preterm labor (1). The presence of fFN in the cervico-vaginal secretions of symptomatic women during weeks 24 through 34 of gestation (5 1/2 to 8 1/2 months) indicates an increased risk of preterm delivery. However, the absence of fFN is a much more reliable predictor, indicating that the pregnancy is likely to continue for at least another two weeks.
The Role of Fetal Fibronectin
Fetal fibronectin (fFN) is a protein produced during pregnancy and functions as a biological glue, attaching the fetal sac to the uterine lining. During the first trimester and for about half of the second trimester (up to 22 weeks of gestation), fFN is normally present in the cervico-vaginal secretions of pregnant women. In most pregnancies, after 22 weeks, this protein is no longer detected until the end of the last trimester (one to three weeks before labor).
The presence of fFN during weeks 24-34 of a high-risk pregnancy, along with symptoms of labor, suggests that the "glue" may be disintegrating ahead of schedule and alerts doctors to a possibility of preterm delivery.
A number of factors are associated with a high risk of preterm delivery. Leading risk factors include a previous preterm birth, multiple pregnancy, an incompetent cervix (a cervix that dilates too early in the pregnancy), uterine abnormalities and amniotic fluid infection. Additional risk factors include vaginal infections and sexually transmitted diseases, maternal smoking and drug abuse, poor nutrition, extremes of maternal weight, and lack of prenatal care. Stress, genetic predisposition and environmental toxins may also contribute to preterm delivery.
The fFN Test
A cotton swab is used to collect samples of cervico-vaginal secretions during a speculum examination (similar to a Pap smear). The analysis of the collected sample usually takes less than 24 hours to complete. The result is either positive (fFN is present) or negative (fFN is not present). The results are valid for up to two weeks from the date of the test.
Recommendations
The greatest value of the fFN test is the high level of reliability of a negative test result. According to ACOG, “Fetal fibronectin testing may be useful in women with symptoms of preterm labor to identify those with negative values and a reduced risk of preterm birth, thereby avoiding unnecessary intervention” (1)
In women with symptoms of preterm labor, a positive fFN result, while less reliable, allows doctors and patients to take preventive measures to delay labor for as long as possible and to consider labor-suppressing (tocolytic) medications.
If the results of fFN negative screening would affect treatment, testing may also be appropriate for women who are asymptomatic, but at high risk of preterm birth. Screening for these women may be done at 24-34 weeks gestation to assist in clinical management (2). In these cases, a negative test result would help prevent unnecessary medical interventions, such as bedrest, prenatal corticosteroids, cervical cerclage, hospitalization and tocolytics.
ACOG currently does not recommend routine fFN screening of pregnant women, as its use has not been shown to be clinically effective in predicting preterm labor in low-risk, asymptomatic pregnancies.